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Optimizing Dosage Forms for Improved Therapeutic Compliance
The oral route of administering medicines remains the most common for many reasons including cost, convenience and public familiarity. Of the oral dosage forms available, tablets and capsules are often the most well known and therefore the default choice for pharmaceutical and healthcare companies. However, …
Formulation Development & Manufacturing – Special Feature in DRUG DEVELOPMENT & DELIVERY
Contract development and manufacturing organizations (CDMOs) are constantly evolving, offering new services to customers to highlight their strengths and to differentiate themselves in the market place.In this Drug Development & Delivery Special Feature, Dr Martin Koeberle (Head of Analytical Development and Stability Testing at HERMES …
Innovation through User-Friendly Dosage Forms
Pharmaceutical companies are under constant pressure to innovate in order to increase revenue. Approaches that had been successfull in the past are increasingly falling short. Time for a closer look at user-friendly dosage forms as a concept to create additional value for patients.Interview conducted by …
The TOPO Granulation Technology Used in the Manufacture of Effervescent Tablets
The effervescent tablet has proven to be a very user-friendly dosage form for the intake of pharmaceuticals. For the pharmaceutical industry, effervescent tablets represent a means to expand product lines, prolong product life cycles and thus expand market share.bene-Arzneimittel is a mid-sized, internationally-operating family business …
Problem-solving Ingredients for Complex Drugs
Around 40% of new chemical entities fall into class II – low solubility drugs, making them difficult to formulate. Improving the bioavailability of these compounds is a major challenge but the technologies involved could help to extend the lifecycle of many medicines. Manufacturers are also …
Hot Melt Coating Comes of Age
Effective medical treatment using self-administered medicines often hinges on patient compliance. This is particularly true when repeated or multiple doses are required, or for those patients who may find it difficult to swallow solid tablets, such as children, the elderly or people suffering from esophagitis. …
A Taste of Your Own Medicine
For example, solid tablets can be large, uncomfortable and even painful to swallow. Research has shown that factors including tablet size, shape and ease-of-swallowing can significantly affect treatment preference, adherence and, subsequently, effectiveness. Given these factors, there is an unmet market need for making medicines …
Putting The Fizz Into Formulation
Effervescent dosage forms offer a wide range of benefits. First and foremost, drinkable medicines are much easier to swallow than conventional solid tablets or capsules. This is worth noting, as many patients complain that swallowing tablets is painful and unpleasant, with factors such as tablet …
Can Pharma Defy Gravity at the Patent Cliff?
Generic-drug competition has become increasingly aggressive, especially in an environment where healthcare policies are placing stronger emphasis on pharmacoeconomics and demanding better treatment outcomes at a lower cost. A 2012 analysis by IMS Health estimated that patent expiries will reduce brand spending in developed markets …
Solvent-free Coating of Traditional and User-friendly Dosage Forms
Tablets and capsules are often coated for various reasons such as to improve their appearance or to make them easier to swallow. Coatings also play an important role in maintaining drug stability, activity, and effectiveness. This article reviews the benefits of solvent-free processes and techniques …