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Improving the bioavailability and solubility of molecules - Special feature of Drug Development & Delivery, March 2020

Improving Bioavailability & Solubility: Understand Your Molecule

Poor bioavailability and solubility are key factors in the failure of many small molecule drugs to reach the market. To alleviate these challenges, drug developers are increasingly turning to specialist formulation partners to leverage their expertise in bioavailability- and solubility-enhancing techniques. Special feature published in DRUG DEVELOPMENT & DELIVERY.

With many promising drugs failing to reach the market on account of poor bioavailability and solubility, the pharmaceutical industry’s need for innovative methods to overcome these challenges is growing. As such, drug developers are looking to the specialist formulation expertise and novel technologies provided by contract manufacturers and developers. This article, published in Drug Development & Delivery, features contributions from HERMES PHARMA’s Martin Koeberle (Head of Analytical Development & Stability Testing), who discusses:

  • How user-friendly dosage forms, such as effervescent and chewable tablets, are ideally suited to enhancing the bioavailability and solubility of small molecule products

  • How 3D-printing offers exciting possibilities for pharmaceutical manufacturing, especially for user-friendly dosage forms

  • The impact of computer-aided formulation development and its associated challenges