Improving the granule strength of roller-compacted ibuprofen sodium for hot-melt coating processing

Solvent-free hot-melt coating processing is a novel and cost-efficient approach to manufacturing taste-masked multiparticulate systems. However, most API powders are fine and cohesive and not processable by hot-melt coating. The aim of this study was to produce dense and abrasion-resistant granules with high drug content (>80%) via roller compaction for hot-melt coating process optimization. The selected API was ibuprofen sodium dihydrate, a salt of ibuprofen with improved bioavailability and poor intrinsic compactibility.

A PDF version of the paper Improving the granule strength of roller-compacted ibuprofen sodium for hot-melt coating processing can be acquired on ScienceDirect.

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