HERMES PHARMA has developed unique technology for carrying out single pot granulation. Our patented TOPO technology produces granules for tablets which contain at least one solid crystalline, organic acid and one alkaline or alkaline earth metal carbonate that reacts with the organic acid in aqueous solution to form carbon dioxide.

TOPO granulation technology comprises a one-step vacuum system, under fully instrumented in-process control (IPC). The process modifies the surface of carrier materials with resultant alterations in their binding mechanisms. Tablets from these granules have excellent hardness and stability.

TOPO granulation requires only a very small quantity of liquid to start the chain reaction. In contrast to other technologies that require e.g. acetone, TOPO uses only pure water or water-ethanol mixtures for granulation. As a result, there are no solvent residues in the finished products.

Continuous Flow (CF) technology is our second generation granulation technology and is designed especially for high throughput granulation. The technology does not need any liquid to start the chain reaction.

Granulation is carried out in an inclined drum into which powder is fed at one end and granulate removed at the other. The drum is rotated in a way which is designed to eliminate almost all shear forces. The process results in granules with a surface protected by inactive components that do not harm sensitive APIs.

CF technology enables us to produce up to 12 tons of granules every day – ideal for products that require large volumes of granules per single dosage form. With no need to add any solvents like acetone, there are no solvent residues in the finished product.